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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38917
http://purl.obolibrary.org/obo/NCIT_C38917
|
|---|---|
| Preferred Name | Interleukin-12 Receptor Subunit Beta-1 |
| Definitions |
Interleukin-12 receptor subunit beta-1 (662 aa, ~73 kDa) is encoded by the human IL12RB1 gene. This protein plays a role in interleukin-12 binding and signal transduction.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Interleukin-12 receptor subunit beta-1 (662 aa, ~73 kDa) is encoded by the human IL12RB1 gene. This protein plays a role in interleukin-12 binding and signal transduction. |
|---|---|
| prefLabel | Interleukin-12 Receptor Subunit Beta-1
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| label | Interleukin-12 Receptor Subunit Beta-1
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| code | C38917
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| prefixIRI | NCIT:C38917
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| OMIM_Number | 601604
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| in_subset | |
| Display_Name | Interleukin-12 Receptor Subunit Beta-1
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| Preferred_Name | Interleukin-12 Receptor Subunit Beta-1
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| Contributing_Source | CTRP
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| Swiss_Prot | P42701
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| Legacy Concept Name | Interleukin-12-Receptor_Beta-1-Chain
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| DesignNote | Interleukin-12 receptor subunit beta-1 is a type I transmembrane disulfide-linked dimer/oligomer containing 5 fibronectin type-III domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. IL12RB1 oligomers act as a low affinity IL12 receptor; the high affinity IL12 receptor is composed of IL12RB1 and IL12RB2. Heterodimers containin one IL12RB1 and one IL23R are receptors for interleukin-23. (UniProt)
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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| UMLS_CUI | C1700851
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