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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38915
http://purl.obolibrary.org/obo/NCIT_C38915
|
|---|---|
| Preferred Name | Interleukin 12 Receptor |
| Definitions |
Human high affinity Interleukin 12 Receptor is composed of Interleukin 12 Receptor Beta 1 Chain (I12RB1) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2), each a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in IL12 signal transduction, IL12RB1 and IL12RB2 oligomers act as low affinity IL12 receptors. (NCI)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Human high affinity Interleukin 12 Receptor is composed of Interleukin 12 Receptor Beta 1 Chain (I12RB1) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2), each a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in IL12 signal transduction, IL12RB1 and IL12RB2 oligomers act as low affinity IL12 receptors. (NCI) |
|---|---|
| label | Interleukin 12 Receptor
|
| prefLabel | Interleukin 12 Receptor
|
| Legacy Concept Name | Interleukin-12_Receptor
|
| in_subset | |
| Preferred_Name | Interleukin 12 Receptor
|
| Display_Name | Interleukin 12 Receptor
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| UMLS_CUI | C0255732
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| FDA_UNII_Code | 35PXZ22YJE
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| prefixIRI | NCIT:C38915
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C38915
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| type | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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