loading...| Preferred Name | Interleukin-1 Receptor Type 1 | |
| Synonyms |
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|
| Definitions |
Interleukin-1 receptor type 1 (569 aa, ~65 kDa) is encoded by the human IL1R1 gene. This protein is involved in interleukin-1 binding and the positive regulation of signal transduction. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C38912 |
|
| code |
C38912 |
|
| Contributing_Source |
CTRP |
|
| definition |
Interleukin-1 receptor type 1 (569 aa, ~65 kDa) is encoded by the human IL1R1 gene. This protein is involved in interleukin-1 binding and the positive regulation of signal transduction. |
|
| DesignNote |
Interleukin-1 receptor type 1 is a type I membrane protein cytokine receptor for IL1A and IL1B, binds to IL1RAP, and contains 3 IgC2 domains and 1 TIR domain. Agonist binding leads to formation of a ternary signaling complex of IL1RAP/TOLLIP/MYD88/IRAK1 (or IRAK2) and NF-Kappa-B activation. |
|
| Display_Name |
Interleukin-1 Receptor Type 1 |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
|
| label |
Interleukin-1 Receptor Type 1 |
|
| Legacy Concept Name |
Interleukin-1-Receptor_Alpha_Type-I |
|
| OMIM_Number |
147810 |
|
| Preferred_Name |
Interleukin-1 Receptor Type 1 |
|
| prefixIRI |
NCIT:C38912 |
|
| prefLabel |
Interleukin-1 Receptor Type 1 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
|
| Swiss_Prot |
P14778 |
|
| UMLS_CUI |
C1700970 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/PR_000001363 | PR | LOOM | |
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38912 | NCIT | LOOM |