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Biological and Environmental Research Ontology
| Preferred Name | Thyroid Gland Medullary Carcinoma | |
| Synonyms |
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| Definitions |
A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C3879 |
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| ALT_DEFINITION |
Carcinoma arising from the C-cells of the thyroid gland. Cancer that develops in C cells of the thyroid. The C cells make a hormone (calcitonin) that helps maintain a healthy level of calcium in the blood. A neuroendocrine malignant epithelial neoplasm arising from C-cells of the thyroid gland.
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| code |
C3879
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| Contributing_Source |
Cellosaurus CDISC CTEP CTRP GDC NICHD
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| definition |
A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy.
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| Display_Name |
Thyroid Gland Medullary Carcinoma
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C168656 http://purl.obolibrary.org/obo/NCIT_C77526 http://purl.obolibrary.org/obo/NCIT_C103059 http://purl.obolibrary.org/obo/NCIT_C90259 http://purl.obolibrary.org/obo/NCIT_C102905 http://purl.obolibrary.org/obo/NCIT_C168662 http://purl.obolibrary.org/obo/NCIT_C168661 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/ncit#oncotree_slim http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C118467 http://purl.obolibrary.org/obo/NCIT_C126659 http://purl.obolibrary.org/obo/NCIT_C88025 http://purl.obolibrary.org/obo/NCIT_C165258 http://purl.obolibrary.org/obo/NCIT_C118168 |
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| Is_Value_For_GDC_Property | ||
| label |
Thyroid Gland Medullary Carcinoma
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| Legacy Concept Name |
Medullary_Thyroid_Carcinoma
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| Maps_To |
Parafollicular cell carcinoma C cell carcinoma Medullary thyroid carcinoma 8345/3
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| Neoplastic_Status |
Malignant
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| Preferred_Name |
Thyroid Gland Medullary Carcinoma
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| prefixIRI |
NCIT:C3879
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| prefLabel |
Thyroid Gland Medullary Carcinoma
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| Semantic_Type |
Neoplastic Process
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| UMLS_CUI |
C0238462
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| subClassOf |
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