loading...| Preferred Name |
Anakinra |
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| Synonyms |
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| Definitions |
A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C38717 |
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| Accepted_Therapeutic_Use_For |
Rheumatoid arthritis |
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| ALT_DEFINITION |
A substance that is used to treat rheumatoid arthritis, and is being studied in the treatment of cancer. Anakinra blocks the action of interleukin 1 (IL-1). It is a type of interleukin receptor antagonist. |
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| CAS_Registry |
143090-92-0 |
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| code |
C38717 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04) |
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| Display_Name |
Anakinra |
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| FDA_UNII_Code |
9013DUQ28K |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Related_To_Endogenous_Product | ||
| Is_Value_For_GDC_Property | ||
| label |
Anakinra |
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| Legacy Concept Name |
Anakinra |
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| Maps_To |
Anakinra |
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| NCI_Drug_Dictionary_ID |
43007 |
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| PDQ_Closed_Trial_Search_ID |
43007 |
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| PDQ_Open_Trial_Search_ID |
43007 |
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| Preferred_Name |
Anakinra |
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| prefixIRI |
NCIT:C38717 |
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| prefLabel |
Anakinra |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0245109 |
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| subClassOf |