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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38709
http://purl.obolibrary.org/obo/NCIT_C38709
|
|---|---|
| Preferred Name | Deslorelin |
| Definitions |
A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04) |
|---|---|
| prefLabel | Deslorelin
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| label | Deslorelin
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| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 357620
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| code | C38709
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| Has_Target | |
| prefixIRI | NCIT:C38709
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| in_subset |
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| Display_Name | Deslorelin
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| Preferred_Name | Deslorelin
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| FDA_UNII_Code | TKG3I66TVE
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C64H83N17O12
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| Maps_To | Deslorelin
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| CAS_Registry | 57773-65-6
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| NCI_Drug_Dictionary_ID | 357620
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| Legacy Concept Name | Deslorelin
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of cancer as a way to block sex hormones made by the ovaries or testicles. It is a type of gonadotropin-releasing hormone analog.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 357620
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| Accepted_Therapeutic_Use_For | Central precocious puberty
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0083220
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