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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C38701
http://purl.obolibrary.org/obo/NCIT_C38701
|
|---|---|
| Preferred Name | Lutetium Lu 177 Rosopatamab Tetraxetan |
| Definitions |
A radioimmunoconjugate consisting of rosopatamab, a humanized monoclonal antibody (MoAb) against the external domain of the prostate-specific membrane antigen (PSMA) that is linked, via the chelating agent, dodecanetetraacetic acid (DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity and imaging activity during single-photon emission computerized tomography/computerized tomography (SPECT/CT). Upon administration, lutetium Lu 177 rosopatamab tetraxetan binds to PSMA expressed on certain tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to PSMA-expressing cells. PSMA is overexpressed in the malignant prostate and its metastases.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate consisting of rosopatamab, a humanized monoclonal antibody (MoAb) against the external domain of the prostate-specific membrane antigen (PSMA) that is linked, via the chelating agent, dodecanetetraacetic acid (DOTA), to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity and imaging activity during single-photon emission computerized tomography/computerized tomography (SPECT/CT). Upon administration, lutetium Lu 177 rosopatamab tetraxetan binds to PSMA expressed on certain tumor cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to PSMA-expressing cells. PSMA is overexpressed in the malignant prostate and its metastases. |
|---|---|
| prefLabel | Lutetium Lu 177 Rosopatamab Tetraxetan
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| label | Lutetium Lu 177 Rosopatamab Tetraxetan
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| PDQ_Closed_Trial_Search_ID | 361550
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| code | C38701
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| Has_Target | |
| prefixIRI | NCIT:C38701
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| in_subset |
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| Display_Name | Lutetium Lu 177 Rosopatamab Tetraxetan
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| Preferred_Name | Lutetium Lu 177 Rosopatamab Tetraxetan
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| FDA_UNII_Code | JB9647672Z
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Lutetium Lu 177 Monoclonal Antibody J591
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| NCI_Drug_Dictionary_ID | 361550
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| Legacy Concept Name | Lutetium_Lu_177_Monoclonal_Antibody_J591
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 361550
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C1518042
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