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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38697
http://purl.obolibrary.org/obo/NCIT_C38697
|
|---|---|
| Preferred Name | Sontuzumab |
| Definitions |
A humanized monoclonal antibody directed against the tumor associated antigen (TAA) mucin-1 (MUC1), with potential antineoplastic activity. Upon administration, sontuzumab targets and binds to MUC1 expressed on the surface of tumor cells, which may activate the immune system to induce an antibody-dependent cellular cytotoxicity (ADCC) against MUC1-expressing tumor cells. MUC1, a glycoprotein overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized monoclonal antibody directed against the tumor associated antigen (TAA) mucin-1 (MUC1), with potential antineoplastic activity. Upon administration, sontuzumab targets and binds to MUC1 expressed on the surface of tumor cells, which may activate the immune system to induce an antibody-dependent cellular cytotoxicity (ADCC) against MUC1-expressing tumor cells. MUC1, a glycoprotein overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation. |
|---|---|
| prefLabel | Sontuzumab
|
| label | Sontuzumab
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| PDQ_Closed_Trial_Search_ID | 322247
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| code | C38697
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| Has_Target | |
| prefixIRI | NCIT:C38697
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| in_subset |
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| Display_Name | Sontuzumab
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| Preferred_Name | Sontuzumab
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| FDA_UNII_Code | 3VD89OE565
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Monoclonal Antibody HuHMFG1
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| CAS_Registry | 372075-37-1
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| NCI_Drug_Dictionary_ID | 322247
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| Legacy Concept Name | Monoclonal_Antibody_HuHMFG1
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| type | |
| ALT_DEFINITION | A monoclonal antibody that binds to the protein MUC1, which is found on breast, ovarian, pancreatic, gastric, and colon cancer cells. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. HuHMFG1 is being studied in the treatment of some types of cancer.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 322247
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
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| UMLS_CUI | C1328704
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