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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38694
http://purl.obolibrary.org/obo/NCIT_C38694
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|---|---|
| Preferred Name | Liposome-encapsulated OSI-7904 |
| Definitions |
A liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904. (NCI04) |
|---|---|
| prefLabel | Liposome-encapsulated OSI-7904
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| label | Liposome-encapsulated OSI-7904
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| PDQ_Closed_Trial_Search_ID | 352016
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| code | C38694
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| prefixIRI | NCIT:C38694
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| in_subset | |
| Preferred_Name | Liposome-encapsulated OSI-7904
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| FDA_UNII_Code | ON177ZCE7M
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| Contributing_Source | FDA
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| Maps_To | Liposome-encapsulated OSI-7904
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| CAS_Registry | 139987-54-5
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| NCI_Drug_Dictionary_ID | 352016
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| Legacy Concept Name | OSI-7904L
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called thymidylate synthase inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 352016
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| Semantic_Type | Pharmacologic Substance
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| UMLS_CUI | C1328144
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