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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38693
http://purl.obolibrary.org/obo/NCIT_C38693
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|---|---|
| Preferred Name | Paricalcitol |
| Definitions |
A synthetic noncalcemic, nonphosphatemic vitamin D analogue. Paricalcitol binds to the vitamin D receptor and has been shown to reduce parathyroid hormone (PTH) levels. This agent also increases the expression of PTEN ('Phosphatase and Tensin homolog deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic cells and cyclin-dependent kinase inhibitors, resulting in tumor cell apoptosis and tumor cell differentiation into normal phenotypes. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic noncalcemic, nonphosphatemic vitamin D analogue. Paricalcitol binds to the vitamin D receptor and has been shown to reduce parathyroid hormone (PTH) levels. This agent also increases the expression of PTEN ('Phosphatase and Tensin homolog deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic cells and cyclin-dependent kinase inhibitors, resulting in tumor cell apoptosis and tumor cell differentiation into normal phenotypes. (NCI04) |
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| prefLabel | Paricalcitol
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| label | Paricalcitol
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| CHEBI_ID | CHEBI:7931
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| PDQ_Closed_Trial_Search_ID | 315740
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| code | C38693
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| prefixIRI | NCIT:C38693
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| in_subset |
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| Display_Name | Paricalcitol
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| Preferred_Name | Paricalcitol
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| FDA_UNII_Code | 6702D36OG5
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C27H44O3
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| Maps_To | Paricalcitol
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| CAS_Registry | 131918-61-1
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| NCI_Drug_Dictionary_ID | 315740
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| Legacy Concept Name | Paricalcitol
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| type | |
| ALT_DEFINITION | A substance that is being used to treat overactive parathyroid glands in patients with kidney failure. It is also being studied in the treatment of cancer. Paricalcitol belongs to the family of drugs called vitamin D analogs.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 315740
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| Accepted_Therapeutic_Use_For | Secondary hyperparathyroidism, prevention and treatment
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0724464
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