loading...| Preferred Name |
Pertuzumab |
|
| Synonyms |
|
|
| Definitions |
A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C38692 |
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| ALT_DEFINITION |
A monoclonal antibody that is being studied in the treatment of cancer. Monoclonal antibodies are produced in the laboratory and can locate and bind to cancer cells. |
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| CAS_Registry |
380610-27-5 |
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| code |
C38692 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04) |
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| Display_Name |
Pertuzumab |
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| FDA_UNII_Code |
K16AIQ8CTM |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Pertuzumab |
|
| Legacy Concept Name |
Pertuzumab |
|
| Maps_To |
Pertuzumab |
|
| NCI_Drug_Dictionary_ID |
322808 |
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| NSC Number |
740102 |
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| PDQ_Closed_Trial_Search_ID |
322808 |
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| PDQ_Open_Trial_Search_ID |
322808 |
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| Preferred_Name |
Pertuzumab |
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| prefixIRI |
NCIT:C38692 |
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| prefLabel |
Pertuzumab |
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| Semantic_Type |
Pharmacologic Substance Immunologic Factor |
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| UMLS_CUI |
C1328025 |
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| subClassOf |