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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38614
http://purl.obolibrary.org/obo/NCIT_C38614
|
|---|---|
| Preferred Name | Adenosine Receptor A2b |
| Definitions |
Adenosine receptor A2b (332 aa, ~36 kDa) is encoded by the human ADORA2B gene. This protein is involved in signaling and cellular defense.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Adenosine receptor A2b (332 aa, ~36 kDa) is encoded by the human ADORA2B gene. This protein is involved in signaling and cellular defense. |
|---|---|
| prefLabel | Adenosine Receptor A2b
|
| label | Adenosine Receptor A2b
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| code | C38614
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| prefixIRI | NCIT:C38614
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| OMIM_Number | 600446
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| in_subset | |
| Display_Name | Adenosine Receptor A2b
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| Preferred_Name | Adenosine Receptor A2b
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| Contributing_Source | CTRP
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| Swiss_Prot | P29275
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| Legacy Concept Name | Adenosine-A2B_Receptor
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| DesignNote | Encoded by human ADORA2B Gene (GPCR1 Family), 332-aa 360-kDa Adenosine A2B Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate cAMP accumulation through adenylate cyclase activation. ADORA2B is also a Netrin-1 receptor in axon elongation, inducing cAMP accumulation. Netrin-1 also binds DCC, which interacts with ADORA2B as well; Netrin-1 growth-promotion may require a DCC/A2B receptor complex or act through DCC independently of ADORA2B. Cycling expression of clock gene Period-1 (rodent) depends on adenosine A2B receptor, which occurs through nocturnal activation of melatonin Mt1 receptors.
Protein_Plays_Role_In_Biological_Process: Axon Elongation
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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| UMLS_CUI | C0667931
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