loading...| Preferred Name |
Adenosine Receptor A2a |
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| Synonyms |
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| Definitions |
Adenosine receptor A2a (412 aa, ~45 kDa) is encoded by the human ADORA2A gene. This protein plays a role in G protein-coupled receptor signaling, phagocytosis, blood circulation, inflammatory response, sensory perception and central nervous system development |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C38612 |
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| code |
C38612 |
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| Contributing_Source |
CTRP |
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| definition |
Adenosine receptor A2a (412 aa, ~45 kDa) is encoded by the human ADORA2A gene. This protein plays a role in G protein-coupled receptor signaling, phagocytosis, blood circulation, inflammatory response, sensory perception and central nervous system development |
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| DesignNote |
Expressed in basal ganglia, vasculature, and platelets by human ADORA2A Gene (GPCR1 Family), 412-aa 45-kDa Adenosine A2A Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate cAMP accumulation through adenylate cyclase activation, is a major target of caffeine, and modulates the activity of various neuronal populations, platelets, neutrophils, and mast cells, and smooth muscle cells in bronchi and vasculature. A potent biologic mediator, most effects of adenosine protect cells during stress. |
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| Display_Name |
Adenosine Receptor A2a |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Adenosine Receptor A2a |
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| Legacy Concept Name |
Adenosine-A2A_Receptor |
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| OMIM_Number |
102776 |
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| Preferred_Name |
Adenosine Receptor A2a |
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| prefixIRI |
NCIT:C38612 |
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| prefLabel |
Adenosine Receptor A2a |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
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| Swiss_Prot |
P29274 |
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| UMLS_CUI |
C0255998 |
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| subClassOf |