Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C38612
http://purl.obolibrary.org/obo/NCIT_C38612
Preferred Name

Adenosine Receptor A2a
Definitions
Adenosine receptor A2a (412 aa, ~45 kDa) is encoded by the human ADORA2A gene. This protein plays a role in G protein-coupled receptor signaling, phagocytosis, blood circulation, inflammatory response, sensory perception and central nervous system development
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Adenosine receptor A2a (412 aa, ~45 kDa) is encoded by the human ADORA2A gene. This protein plays a role in G protein-coupled receptor signaling, phagocytosis, blood circulation, inflammatory response, sensory perception and central nervous system development
prefLabel
Adenosine Receptor A2a
label
Adenosine Receptor A2a
code
C38612
prefixIRI
NCIT:C38612
OMIM_Number
102776
in_subset
Display_Name
Adenosine Receptor A2a
Preferred_Name
Adenosine Receptor A2a
Contributing_Source
CTRP
Swiss_Prot
P29274
Legacy Concept Name
Adenosine-A2A_Receptor
DesignNote
Expressed in basal ganglia, vasculature, and platelets by human ADORA2A Gene (GPCR1 Family), 412-aa 45-kDa Adenosine A2A Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate cAMP accumulation through adenylate cyclase activation, is a major target of caffeine, and modulates the activity of various neuronal populations, platelets, neutrophils, and mast cells, and smooth muscle cells in bronchi and vasculature. A potent biologic mediator, most effects of adenosine protect cells during stress.
type
subClassOf
Semantic_Type
Amino Acid, Peptide, or Protein
Receptor
UMLS_CUI
C0255998
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