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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C38142
http://purl.obolibrary.org/obo/NCIT_C38142
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|---|---|
| Preferred Name | Alvespimycin |
| Definitions |
An analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. |
|---|---|
| prefLabel | Alvespimycin
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| label | Alvespimycin
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| Has_Salt_Form | |
| code | C38142
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| Has_Target | |
| prefixIRI | NCIT:C38142
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| in_subset | |
| Preferred_Name | Alvespimycin
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| FDA_UNII_Code | 001L2FE0M3
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| Contributing_Source | FDA
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| Chemical_Formula | C32H48N4O8
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| Maps_To | Alvespimycin
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| CAS_Registry | 467214-20-6
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| NSC Number | 707545
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| Legacy Concept Name | _17-Dimethylaminoethylamino_17-Demethoxygeldanamycin
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| type | |
| ALT_DEFINITION | 17-DMAG. A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called geldanamycin analogs.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C1527262
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