Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C38129 http://purl.obolibrary.org/obo/NCIT_C38129
Preferred Name	Methionine Aminopeptidase 2 Inhibitor PPI-2458
Definitions	A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class. (NCI04)
Type	http://www.w3.org/2002/07/owl#Class

definition	A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class. (NCI04)
prefLabel	Methionine Aminopeptidase 2 Inhibitor PPI-2458
label	Methionine Aminopeptidase 2 Inhibitor PPI-2458
PDQ_Closed_Trial_Search_ID	415572
code	C38129
prefixIRI	NCIT:C38129
in_subset	http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Preferred_Name	Methionine Aminopeptidase 2 Inhibitor PPI-2458
FDA_UNII_Code	NA0Y2SRR29
Contributing_Source	FDA
Maps_To	Methionine Aminopeptidase 2 Inhibitor PPI-2458
CAS_Registry	431077-35-9
NSC Number	720735
NCI_Drug_Dictionary_ID	415572
Legacy Concept Name	PPI-2458
type	http://www.w3.org/2002/07/owl#Class
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C2143
PDQ_Open_Trial_Search_ID	415572
Semantic_Type	Pharmacologic Substance
UMLS_CUI	C1505437

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