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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Id | http://purl.obolibrary.org/obo/NCIT_C381
http://purl.obolibrary.org/obo/NCIT_C381
|
|---|---|
| Preferred Name | Clotrimazole |
| Definitions |
A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis. |
|---|---|
| label |
Clotrimazole
|
| prefLabel |
Clotrimazole
|
| Legacy Concept Name |
Clotrimazole
|
| in_subset | |
| Preferred_Name |
Clotrimazole
|
| Chemical_Formula |
C22H17ClN2
|
| PDQ_Open_Trial_Search_ID |
39116
|
| UMLS_CUI |
C0009074
|
| FDA_UNII_Code |
G07GZ97H65
|
| prefixIRI |
NCIT:C381
|
| NCI_Drug_Dictionary_ID |
39116
|
| Contributing_Source |
FDA
|
| subClassOf | |
| CHEBI_ID |
CHEBI:3764
|
| code |
C381
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| type | |
| NSC Number |
257473
|
| PDQ_Closed_Trial_Search_ID |
39116
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
|
| CAS_Registry |
23593-75-1
|
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