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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C376
http://purl.obolibrary.org/obo/NCIT_C376
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|---|---|
| Preferred Name | Cisplatin |
| Definitions |
An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. |
|---|---|
| prefLabel | Cisplatin
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| label | Cisplatin
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| CHEBI_ID | CHEBI:27899
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| PDQ_Closed_Trial_Search_ID | 39515
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| code | C376
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| prefixIRI | NCIT:C376
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| in_subset |
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| Display_Name | Cisplatin
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| Preferred_Name | Cisplatin
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| FDA_UNII_Code | Q20Q21Q62J
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| Contributing_Source |
CTRP
FDA
PCDC
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| Chemical_Formula | 2Cl.Pt.2H3N
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| Maps_To | Cisplatin
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| CAS_Registry | 15663-27-1
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| NSC Number | 119875
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| NCI_Drug_Dictionary_ID | 39515
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| Legacy Concept Name | Cisplatin
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| Is_PCDC_GCT_Permissible_Value_For_Variable | |
| type | |
| ALT_DEFINITION | A drug used to treat many types of cancer. Cisplatin contains the metal platinum. It kills cancer cells by damaging their DNA and stopping them from dividing. Cisplatin is a type of alkylating agent.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39515
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| Accepted_Therapeutic_Use_For | metastatic testicular cancer; ovarian cancer; head and neck cancer; breast cancer; Hodgkin's and non-Hodgkin's lymphoma; myeloma and melanoma
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| Semantic_Type |
Pharmacologic Substance
Inorganic Chemical
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| UMLS_CUI | C0008838
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