Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C37452
http://purl.obolibrary.org/obo/NCIT_C37452
Preferred Name

Ixabepilone
Definitions
An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines.
prefLabel
Ixabepilone
label
Ixabepilone
CHEBI_ID
CHEBI:63605
PDQ_Closed_Trial_Search_ID
37860
code
C37452
Has_Target
prefixIRI
NCIT:C37452
in_subset
Display_Name
Ixabepilone
Preferred_Name
Ixabepilone
FDA_UNII_Code
K27005NP0A
Contributing_Source
CTRP
FDA
Chemical_Formula
C27H42N2O5S
Maps_To
Ixabepilone
CAS_Registry
219989-84-1
NSC Number
710428
NCI_Drug_Dictionary_ID
37860
Legacy Concept Name
Ixabepilone
type
ALT_DEFINITION
A drug used to treat metastatic or locally advanced breast cancer that has not improved after treatment with certain other anticancer drugs. It is also being studied in the treatment of other types of cancer. Ixempra stops the growth of tumor cells by blocking cell division. It is a type of epothilone analog.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
37860
Accepted_Therapeutic_Use_For
metastatic or locally advanced breast cancer.
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C1135132
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