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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C374
http://purl.obolibrary.org/obo/NCIT_C374
|
|---|---|
| Preferred Name | Cimetidine |
| Definitions |
A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04) |
|---|---|
| prefLabel | Cimetidine
|
| label | Cimetidine
|
| Has_Salt_Form | |
| CHEBI_ID | CHEBI:3699
|
| PDQ_Closed_Trial_Search_ID | 39185
|
| code | C374
|
| Has_Target | |
| prefixIRI | NCIT:C374
|
| in_subset |
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| Display_Name | Cimetidine
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| Preferred_Name | Cimetidine
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| FDA_UNII_Code | 80061L1WGD
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C10H16N6S
|
| Maps_To | Cimetidine
|
| CAS_Registry | 51481-61-9
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| NSC Number | 335308
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| NCI_Drug_Dictionary_ID | 39185
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| Legacy Concept Name | Cimetidine
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| type | |
| ALT_DEFINITION | A drug usually used to treat stomach ulcers and heartburn. It is also commonly used in a regimen to prevent allergic reactions.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39185
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| Accepted_Therapeutic_Use_For | Gastrointestinal conditions; allergic reaction prevention; immune modulation
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0008783
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