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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C37274
http://purl.obolibrary.org/obo/NCIT_C37274
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|---|---|
| Preferred Name | Interferon Alpha Receptor Complex |
| Definitions |
Human Interferon Alpha Receptor Complex (Type II Cytokine Family Receptor) is a ubiquitous type I membrane protein heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Human Interferon Alpha Receptor Complex (Type II Cytokine Family Receptor) is a ubiquitous type I membrane protein heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI) |
|---|---|
| prefLabel | Interferon Alpha Receptor Complex
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| label | Interferon Alpha Receptor Complex
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| code | C37274
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| prefixIRI | NCIT:C37274
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| in_subset | |
| Display_Name | Interferon Alpha Receptor Complex
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| Preferred_Name | Interferon Alpha Receptor Complex
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| Contributing_Source | CTRP
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| Legacy Concept Name | Interferon_Alpha_Receptor_Complex
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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| UMLS_CUI | C0254653
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