Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Digestive System Adenoma
Synonyms
Definitions

A sporadic or less frequently familial neoplasm that arises from the glandular epithelium of the gastrointestinal tract and liver. In the gastrointestinal tract, it manifests as a polypoid or flat circumscribed lesion. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and is associated with dysplasia. Based on the growth pattern, it may be classified as tubular, villous, or tubulovillous. The dysplasia is classified as mild, moderate, or severe. The frequency of malignant transformation depends on the size of the lesion and the degree of dysplasia. Larger gastrointestinal tract adenomas with severe dysplastic changes carry a higher risk of progression to invasive adenocarcinoma. Gastrointestinal adenomas may present as solitary or multifocal lesions. In the liver, it arises from the hepatocytes. Grossly, it appears as a soft, round mass. Morphologically, the neoplastic cells resemble normal hepatocytes.
ID

http://purl.obolibrary.org/obo/NCIT_C36207
code

C36207
definition

A sporadic or less frequently familial neoplasm that arises from the glandular epithelium of the gastrointestinal tract and liver. In the gastrointestinal tract, it manifests as a polypoid or flat circumscribed lesion. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and is associated with dysplasia. Based on the growth pattern, it may be classified as tubular, villous, or tubulovillous. The dysplasia is classified as mild, moderate, or severe. The frequency of malignant transformation depends on the size of the lesion and the degree of dysplasia. Larger gastrointestinal tract adenomas with severe dysplastic changes carry a higher risk of progression to invasive adenocarcinoma. Gastrointestinal adenomas may present as solitary or multifocal lesions. In the liver, it arises from the hepatocytes. Grossly, it appears as a soft, round mass. Morphologically, the neoplastic cells resemble normal hepatocytes.
in_subset

http://purl.obolibrary.org/obo/NCIT_C126659
label

Digestive System Adenoma
Legacy Concept Name

Gastrointestinal_Adenoma
Neoplastic_Status

Benign
Preferred_Name

Digestive System Adenoma
prefixIRI

NCIT:C36207
prefLabel

Digestive System Adenoma
Semantic_Type

Neoplastic Process
UMLS_CUI

C0948101
subClassOf

http://purl.obolibrary.org/obo/NCIT_C4787

http://purl.obolibrary.org/obo/NCIT_C2855
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