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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C349
http://purl.obolibrary.org/obo/NCIT_C349
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|---|---|
| Preferred Name | Carmustine |
| Definitions |
An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04) |
|---|---|
| label | Carmustine
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| prefLabel | Carmustine
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| Legacy Concept Name | Carmustine
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| in_subset |
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| Preferred_Name | Carmustine
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| Is_Value_For_GDC_Property | |
| Chemical_Formula | C5H9Cl2N3O2
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| Display_Name | Carmustine
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| Maps_To | Carmustine
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| PDQ_Open_Trial_Search_ID | 43027
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| UMLS_CUI | C0007257
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| FDA_UNII_Code | U68WG3173Y
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| prefixIRI | NCIT:C349
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| Accepted_Therapeutic_Use_For | Brain tumors; colon cancer; lung cancer; lymphomas; Hodgkins and Non-Hodgkins; melanoma; multiple myeloma; mycosis fungoides
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| NCI_Drug_Dictionary_ID | 43027
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| Contributing_Source |
CTRP
FDA
PCDC
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| subClassOf | |
| CHEBI_ID | CHEBI:3423
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| code | C349
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called alkylating agents.
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| NSC Number | 409962
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| PDQ_Closed_Trial_Search_ID | 43027
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| Semantic_Type |
Pharmacologic Substance
Hazardous or Poisonous Substance
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| CAS_Registry | 154-93-8
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