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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Carbenicillin | |
| Synonyms |
|
|
| Definitions |
A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C343 |
|
| CAS_Registry |
4697-36-3
|
|
| CHEBI_ID |
CHEBI:3393
|
|
| Chemical_Formula |
C17H18N2O6S
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|
| code |
C343
|
|
| Contributing_Source |
FDA
|
|
| definition |
A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis.
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|
| FDA_UNII_Code |
G42ZU72N5G
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|
| Has_Salt_Form | ||
| in_subset | ||
| label |
Carbenicillin
|
|
| Legacy Concept Name |
Carbenicillin
|
|
| NCI_Drug_Dictionary_ID |
39174
|
|
| NSC Number |
111071
|
|
| PDQ_Closed_Trial_Search_ID |
39174
|
|
| PDQ_Open_Trial_Search_ID |
39174
|
|
| Preferred_Name |
Carbenicillin
|
|
| prefixIRI |
NCIT:C343
|
|
| prefLabel |
Carbenicillin
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
|
|
| UMLS_CUI |
C0006976
|
|
| subClassOf |
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