Preferred Name | Captopril | |
Synonyms |
|
|
Definitions |
A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. (NCI04) |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C340 |
|
Accepted_Therapeutic_Use_For |
Hypertension; Heart failure; Left ventricular dysfunction; Diabetic nephropathy |
|
ALT_DEFINITION |
A drug used to treat high blood pressure that is also being studied in the prevention of side effects caused by radiation therapy used in the treatment of cancer. It belongs to the family of drugs called ACE inhibitors. |
|
CAS_Registry |
62571-86-2 |
|
CHEBI_ID |
CHEBI:3380 |
|
Chemical_Formula |
C9H15NO3S |
|
code |
C340 |
|
Contributing_Source |
FDA |
|
definition |
A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. (NCI04) |
|
FDA_UNII_Code |
9G64RSX1XD |
|
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
Is_Value_For_GDC_Property | ||
label |
Captopril |
|
Legacy Concept Name |
Captopril |
|
Maps_To |
Captopril |
|
NCI_Drug_Dictionary_ID |
37824 |
|
NSC Number |
719847 |
|
PDQ_Closed_Trial_Search_ID |
37824 |
|
PDQ_Open_Trial_Search_ID |
37824 |
|
Preferred_Name |
Captopril |
|
prefixIRI |
NCIT:C340 |
|
prefLabel |
Captopril |
|
Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
UMLS_CUI |
C0006938 |
|
subClassOf |