Preferred Name

Captopril
Synonyms
Definitions

A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. (NCI04)

ID

http://purl.obolibrary.org/obo/NCIT_C340

Accepted_Therapeutic_Use_For

Hypertension; Heart failure; Left ventricular dysfunction; Diabetic nephropathy

ALT_DEFINITION

A drug used to treat high blood pressure that is also being studied in the prevention of side effects caused by radiation therapy used in the treatment of cancer. It belongs to the family of drugs called ACE inhibitors.

CAS_Registry

62571-86-2

CHEBI_ID

CHEBI:3380

Chemical_Formula

C9H15NO3S

code

C340

Contributing_Source

FDA

definition

A sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis. (NCI04)

FDA_UNII_Code

9G64RSX1XD

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C173383

http://purl.obolibrary.org/obo/NCIT_C173381

http://purl.obolibrary.org/obo/NCIT_C177537

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C128784

http://purl.obolibrary.org/obo/NCIT_C157711

http://purl.obolibrary.org/obo/NCIT_C157712

Is_Value_For_GDC_Property

http://purl.obolibrary.org/obo/NCIT_C1909

label

Captopril

Legacy Concept Name

Captopril

Maps_To

Captopril

NCI_Drug_Dictionary_ID

37824

NSC Number

719847

PDQ_Closed_Trial_Search_ID

37824

PDQ_Open_Trial_Search_ID

37824

Preferred_Name

Captopril

prefixIRI

NCIT:C340

prefLabel

Captopril

Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance

UMLS_CUI

C0006938

subClassOf

http://purl.obolibrary.org/obo/NCIT_C247

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http://purl.obolibrary.org/obo/OMIT_0003555 OMIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387160004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP32689-9 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/C-80390 SNMI LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000037824 PDQ LOOM
http://bmi.utah.edu/ontologies/hfontology/C0006938 HFO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00021270 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/RXNORM/1998 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/1998 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4017614 VANDF LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#captopril SDO LOOM
http://www.co-ode.org/ontologies/galen#Captopril GALEN LOOM
http://stirdf.jst.go.jp/id/200907010005604619 IOBC LOOM
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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.125.072.401.623.270 RH-MESH LOOM
https://go.drugbank.com/drugs/DB01197 MDM LOOM
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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002216 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP18914-9 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2377 OCHV LOOM
http://purl.bioontology.org/ontology/CSP/0777-7874 CRISP LOOM
http://www.drugbank.ca/drugs/DB01197 FTC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Captopril APAONTO LOOM
http://purl.bioontology.org/ontology/RCD/bi1.. RCD LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000145994 OCVDAE LOOM
http://purl.obolibrary.org/obo/XCO_0000270 XCO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02619 MIO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145994 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D002216 MESH LOOM