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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C33991
http://purl.obolibrary.org/obo/NCIT_C33991
|
|---|---|
| Preferred Name | MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 |
| Definitions |
MAP kinase-interacting serine/threonine-protein kinase 1 (465 aa, ~51 kDa) is encoded by the human MKNK1 gene. This protein may play a role in translation initiation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | MAP kinase-interacting serine/threonine-protein kinase 1 (465 aa, ~51 kDa) is encoded by the human MKNK1 gene. This protein may play a role in translation initiation. |
|---|---|
| prefLabel | MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1
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| label | MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1
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| code | C33991
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| prefixIRI | NCIT:C33991
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| OMIM_Number | 606724
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| in_subset | |
| Display_Name | MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1
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| Preferred_Name | MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1
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| Contributing_Source | CTRP
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| Swiss_Prot | Q9BUB5
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| Legacy Concept Name | MAP-Kinase_Interacting_Kinase-1
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| DesignNote | MAP Kinase Interacting Kinase 1 isoforms contain a typical Ser/Thr kinase domain, an N-terminal putative NLS, and share homology with MAPKAPK2, MAPKAPK3, and p90(RSK). Strongly interacting with, and phosphorylated/activated (via C-terminal region) by, dephosphorylated p38MAP and ERK kinases, but not JNK/SAPK, MKNK1 is activated by many extracellular mitogenic and stress stimuli. Docking with EIF4G1 and -2 C-terminal regions, MNK1 appears to regulate transcription by phosphorylating EIF4E and increasing affinity for the 7-methylG mRNA cap. MNK1 also interacts with the translational inhibitor p97 C- terminus. p97 may sequester MNK1, blocking eIF4E phosphorylation.
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C0539636
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