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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C338
http://purl.obolibrary.org/obo/NCIT_C338
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|---|---|
| Preferred Name | Camptothecin |
| Definitions |
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI) |
|---|---|
| prefLabel | Camptothecin
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| label | Camptothecin
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| Has_Salt_Form | |
| CHEBI_ID | CHEBI:27656
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| PDQ_Closed_Trial_Search_ID | 39173
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| code | C338
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| prefixIRI | NCIT:C338
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| in_subset | |
| Preferred_Name | Camptothecin
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| FDA_UNII_Code | XT3Z54Z28A
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| Contributing_Source | FDA
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| Chemical_Formula | C20H16N2O4
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| Maps_To | Camptothecin
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| CAS_Registry | 7689-03-4
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| NSC Number | 94600
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| NCI_Drug_Dictionary_ID | 39173
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| Legacy Concept Name | Camptothecin
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39173
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0006812
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