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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C321
http://purl.obolibrary.org/obo/NCIT_C321
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|---|---|
| Preferred Name | Busulfan |
| Definitions |
A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04) |
|---|---|
| prefLabel | Busulfan
|
| label | Busulfan
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| CHEBI_ID | CHEBI:28901
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| PDQ_Closed_Trial_Search_ID | 41947
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| code | C321
|
| prefixIRI | NCIT:C321
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| in_subset |
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| Display_Name | Busulfan
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| Preferred_Name | Busulfan
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| FDA_UNII_Code | G1LN9045DK
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| Is_PCDC_AML_Permissible_Value_For_Variable | |
| Contributing_Source |
CTRP
FDA
PCDC
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| Chemical_Formula | C6H14O6S2
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| Maps_To | Busulfan
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| CAS_Registry | 55-98-1
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| NSC Number | 750
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| NCI_Drug_Dictionary_ID | 41947
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| Legacy Concept Name | Busulfan
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called alkylating agents.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41947
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| Accepted_Therapeutic_Use_For | Bone marrow disorders; chronic myelogenous leukemia; palliative; neoadjuvant to allogeneic hematopoietic progenitor cell transplantation; neoplastic meningitis; primary brain malignancies
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0006463
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