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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C320
http://purl.obolibrary.org/obo/NCIT_C320
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|---|---|
| Preferred Name | Buserelin |
| Definitions |
A synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. (NCI04) |
|---|---|
| prefLabel | Buserelin
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| label | Buserelin
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| Has_Salt_Form | |
| PDQ_Closed_Trial_Search_ID | 39170
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| code | C320
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| prefixIRI | NCIT:C320
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| in_subset |
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| Display_Name | Buserelin
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| Preferred_Name | Buserelin
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| FDA_UNII_Code | PXW8U3YXDV
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C60H86N16O13
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| Maps_To | Buserelin
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| CAS_Registry | 57982-77-1
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| NSC Number | 725176
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| NCI_Drug_Dictionary_ID | 39170
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| Legacy Concept Name | Buserelin
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called gonadotropin-releasing hormones. In prostate cancer therapy, buserelin blocks the production of testosterone in the testicles.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39170
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| Accepted_Therapeutic_Use_For | Breast cancer; Contraception, female; Endometriosis; Infertility; in vitro fertilization; Polycystic ovary syndrome; Prostate cancer; Uterine leiomyoma
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0006456
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