Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C318
http://purl.obolibrary.org/obo/NCIT_C318
|
|---|---|
| Preferred Name | Broxuridine |
| Definitions |
A halogenated thymidine analogue with potential antineoplastic and radiosensitizing activities. Bromodeoxyuridine competes with thymidine for incorporation into DNA, resulting in DNA mutation and the inhibition of cell proliferation. As a radiosensitizer, this agent is associated with the inhibition of repair of radiation-induced DNA double-strand breaks.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A halogenated thymidine analogue with potential antineoplastic and radiosensitizing activities. Bromodeoxyuridine competes with thymidine for incorporation into DNA, resulting in DNA mutation and the inhibition of cell proliferation. As a radiosensitizer, this agent is associated with the inhibition of repair of radiation-induced DNA double-strand breaks. |
|---|---|
| prefLabel | Broxuridine
|
| label | Broxuridine
|
| CHEBI_ID | CHEBI:472552
|
| PDQ_Closed_Trial_Search_ID | 39168
|
| code | C318
|
| prefixIRI | NCIT:C318
|
| in_subset |
See more
See less
|
| Display_Name | Broxuridine
|
| Preferred_Name | Broxuridine
|
| FDA_UNII_Code | G34N38R2N1
|
| Contributing_Source |
CTRP
FDA
|
| Chemical_Formula | C9H11BrN2O5
|
| Maps_To | Broxuridine
|
| CAS_Registry | 59-14-3
|
| NSC Number | 38297
|
| NCI_Drug_Dictionary_ID | 39168
|
| Legacy Concept Name | Bromodeoxyuridine
|
| type | |
| ALT_DEFINITION | A drug that makes cancer cells more sensitive to radiation and is also used as a diagnostic agent to determine how fast cancer cells grow.
|
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39168
|
| Semantic_Type |
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
|
| UMLS_CUI | C0006233
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |