loading...| Preferred Name | Chronic Myelogenous Leukemia, BCR-ABL1 Positive | |
| Synonyms |
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| Definitions |
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C3174 |
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| ALT_DEFINITION |
A slowly progressing disease in which too many white blood cells are made in the bone marrow. |
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| code |
C3174 |
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| Contributing_Source |
Cellosaurus CPTAC CTRP GDC |
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| definition |
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival. |
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| Display_Name |
Chronic Myelogenous Leukemia, BCR-ABL1 Positive |
|
| ICD-O-3_Code |
9863/3 9875/3 |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C138190 http://purl.obolibrary.org/obo/NCIT_C168658 http://purl.obolibrary.org/obo/NCIT_C168656 http://purl.obolibrary.org/obo/NCIT_C168657 http://purl.obolibrary.org/obo/NCIT_C168655 http://purl.obolibrary.org/obo/NCIT_C158520 http://purl.obolibrary.org/obo/NCIT_C168662 http://purl.obolibrary.org/obo/NCIT_C168661 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C156952 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C126659 http://purl.obolibrary.org/obo/NCIT_C138188 http://purl.obolibrary.org/obo/NCIT_C165258 http://purl.obolibrary.org/obo/NCIT_C118168 |
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| Is_Value_For_GDC_Property | ||
| label |
Chronic Myelogenous Leukemia, BCR-ABL1 Positive |
|
| Legacy Concept Name |
Chronic_Myelogenous_Leukemia |
|
| Maps_To |
Chronic myeloid leukemia without mention of having achieved remission Chronic myeloid leukaemia [CML], BCR/ABL-positive Chronic myelogenous leukemia, BCR/ABL positive Chronic myelogenous leukemia, BCR-ABL positive Chronic myeloid leukemia, NOS Chronic myelocytic leukemia, NOS Chronic granulocytic leukemia, NOS Myeloid leukemia, chronic Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission 9863/3 9875/3 |
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| Neoplastic_Status |
Malignant |
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| Preferred_Name |
Chronic Myelogenous Leukemia, BCR-ABL1 Positive |
|
| prefixIRI |
NCIT:C3174 |
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| prefLabel |
Chronic Myelogenous Leukemia, BCR-ABL1 Positive |
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| Semantic_Type |
Neoplastic Process |
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| UMLS_CUI |
C0023473 |
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| subClassOf |