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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C30171
http://purl.obolibrary.org/obo/NCIT_C30171
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|---|---|
| Preferred Name | Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform |
| Definitions |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (1102 aa, ~126 kDa) is encoded by the human PIK3CG gene. This protein plays a role in phosphoinositide phosphorylation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (1102 aa, ~126 kDa) is encoded by the human PIK3CG gene. This protein plays a role in phosphoinositide phosphorylation. |
|---|---|
| prefLabel | Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform
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| label | Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform
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| code | C30171
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| prefixIRI | NCIT:C30171
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| OMIM_Number | 601232
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| in_subset | |
| Display_Name | Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform
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| Preferred_Name | Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform
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| Contributing_Source | CTRP
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| Swiss_Prot | P48736
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| Legacy Concept Name | Phosphoinositide-3-Kinase_Catalytic_Gamma_Polypeptide
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| DesignNote | Protein_Plays_Role_In_Biological_Process: Cytotoxicity
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. (from LocusLink)
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C0285761
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