Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C30164
http://purl.obolibrary.org/obo/NCIT_C30164
Preferred Name

Platelet-Derived Growth Factor Receptor Beta
Definitions
Platelet-derived growth factor receptor beta (1106 aa, ~124 kDa) is encoded by the human PDGFRB gene. This protein plays a role in tyrosine phosphorylation and ligand-dependent signal transduction.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Platelet-derived growth factor receptor beta (1106 aa, ~124 kDa) is encoded by the human PDGFRB gene. This protein plays a role in tyrosine phosphorylation and ligand-dependent signal transduction.
prefLabel
Platelet-Derived Growth Factor Receptor Beta
label
Platelet-Derived Growth Factor Receptor Beta
code
C30164
prefixIRI
NCIT:C30164
OMIM_Number
173410
in_subset
Display_Name
Platelet-Derived Growth Factor Receptor Beta
Preferred_Name
Platelet-Derived Growth Factor Receptor Beta
Contributing_Source
CTRP
Swiss_Prot
P09619
Legacy Concept Name
Platelet-Derived_Growth_Factor_Receptor_Beta_Polypeptide
DesignNote
The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia. (from LocusLink)
type
subClassOf
Semantic_Type
Amino Acid, Peptide, or Protein
UMLS_CUI
C0290068
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