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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C30163
http://purl.obolibrary.org/obo/NCIT_C30163
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|---|---|
| Preferred Name | Platelet-Derived Growth Factor Receptor Alpha |
| Definitions |
Platelet-derived growth factor receptor alpha (1089 aa, ~123 kDa) is encoded by the human PDGFRA gene. This protein is involved in ligand binding, tyrosine phosphorylation and receptor signaling.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Platelet-derived growth factor receptor alpha (1089 aa, ~123 kDa) is encoded by the human PDGFRA gene. This protein is involved in ligand binding, tyrosine phosphorylation and receptor signaling. |
|---|---|
| prefLabel | Platelet-Derived Growth Factor Receptor Alpha
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| label | Platelet-Derived Growth Factor Receptor Alpha
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| code | C30163
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| prefixIRI | NCIT:C30163
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| OMIM_Number | 173490
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| in_subset | |
| Display_Name | Platelet-Derived Growth Factor Receptor Alpha
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| Preferred_Name | Platelet-Derived Growth Factor Receptor Alpha
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| Contributing_Source | CTRP
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| Swiss_Prot | P16234
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| Legacy Concept Name | Platelet-Derived_Growth_Factor_Receptor_Alpha_Polypeptide
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| DesignNote | The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. (from LocusLink)
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| type | |
| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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| UMLS_CUI | C0290067
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