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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C30102
http://purl.obolibrary.org/obo/NCIT_C30102
|
|---|---|
| Preferred Name | Toll-Like Receptor 2 |
| Definitions |
Toll-like receptor 2 (784 aa, ~90 kDa) is encoded by the human TLR2 gene. This protein is involved in signal transduction that modulates innate immunity.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Toll-like receptor 2 (784 aa, ~90 kDa) is encoded by the human TLR2 gene. This protein is involved in signal transduction that modulates innate immunity. |
|---|---|
| prefLabel | Toll-Like Receptor 2
|
| label | Toll-Like Receptor 2
|
| code | C30102
|
| prefixIRI | NCIT:C30102
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| OMIM_Number | 603028
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| in_subset | |
| Display_Name | Toll-Like Receptor 2
|
| Preferred_Name | Toll-Like Receptor 2
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| Contributing_Source | CTRP
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| Swiss_Prot | O60603
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| Legacy Concept Name | Toll-Like_Receptor-2
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| DesignNote | Toll-like receptor (TLR) 2 mediates response to microbial lipoproteins and cell wall components. Binding LY96 and TLR6 via the extracellular domains, TLR2 recognizes MALP-2, STF, PSM, and OspA-L with TLR6. TLR2 acts via MyD88 (via their TIR domains) and TRAF6, activating NF-Kappa-B, cytokine secretion, and inflammatory response. TLR2 may promote apoptosis in response to lipoproteins. (UniProt)
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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| UMLS_CUI | C0754727
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