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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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Id | http://purl.obolibrary.org/obo/NCIT_C29842
http://purl.obolibrary.org/obo/NCIT_C29842
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Preferred Name | Nimesulide |
Definitions |
A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04)
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04) |
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label |
Nimesulide
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prefLabel |
Nimesulide
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Legacy Concept Name |
Nimesulide
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in_subset | |
Preferred_Name |
Nimesulide
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Chemical_Formula |
C13H12N2O5S
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UMLS_CUI |
C0132515
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FDA_UNII_Code |
V4TKW1454M
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prefixIRI |
NCIT:C29842
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Contributing_Source |
FDA
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subClassOf | |
CHEBI_ID |
CHEBI:44445
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code |
C29842
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type | |
Semantic_Type |
Pharmacologic Substance
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CAS_Registry |
51803-78-2
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