Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C29487
http://purl.obolibrary.org/obo/NCIT_C29487
Preferred Name

Tazarotene
Definitions
A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04)
prefLabel
Tazarotene
label
Tazarotene
CHEBI_ID
CHEBI:32184
PDQ_Closed_Trial_Search_ID
553530
code
C29487
prefixIRI
NCIT:C29487
in_subset
Display_Name
Tazarotene
Preferred_Name
Tazarotene
FDA_UNII_Code
81BDR9Y8PS
Contributing_Source
CTRP
FDA
Chemical_Formula
C21H21NO2S
Maps_To
Tazarotene
CAS_Registry
118292-40-3
NCI_Drug_Dictionary_ID
553530
Legacy Concept Name
Tazarotene
type
ALT_DEFINITION
A drug used on the skin to treat several skin conditions. It is also being studied in the treatment of basal cell skin cancer and basal cell nevus syndrome. Tazarotene is related to vitamin A and is made in the laboratory. It turns on a gene that may help stop the growth of skin cancer cells. Tazarotene is a type of synthetic retinoid.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
553530
Accepted_Therapeutic_Use_For
Topical treatment of facial acne vulgaris; stable plaque psoriasis; mitigation (palliation) of facial fine wrinkling; facial mottled hyper- and hypopigmentation; benign facial lentigines
Semantic_Type
Pharmacologic Substance
UMLS_CUI
C0288792
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