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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C29483
http://purl.obolibrary.org/obo/NCIT_C29483
|
|---|---|
| Preferred Name | TGFa-PE38 Immunotoxin |
| Definitions |
A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38) without its cell-binding domain. The TGF-alpha moiety of the agent attaches to tumor cells expressing the epithelial growth factor receptor (EGFR); the exotoxin induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38) without its cell-binding domain. The TGF-alpha moiety of the agent attaches to tumor cells expressing the epithelial growth factor receptor (EGFR); the exotoxin induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04) |
|---|---|
| label | TGFa-PE38 Immunotoxin
|
| prefLabel | TGFa-PE38 Immunotoxin
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| Legacy Concept Name | TP-38
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| in_subset | |
| Preferred_Name | TGFa-PE38 Immunotoxin
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| Is_Value_For_GDC_Property | |
| Maps_To | TGFa-PE38 Immunotoxin
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| PDQ_Open_Trial_Search_ID | 346468
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| UMLS_CUI | C1328109
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| prefixIRI | NCIT:C29483
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| NCI_Drug_Dictionary_ID | 346468
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| subClassOf | |
| code | C29483
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| type | |
| ALT_DEFINITION | A substance being studied in the treatment of brain tumors. It combines a protein that binds to certain tumor cells with a bacterial toxin that kills tumor cells.
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| NSC Number | 726586
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| PDQ_Closed_Trial_Search_ID | 346468
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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