Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C29404
http://purl.obolibrary.org/obo/NCIT_C29404
Preferred Name

Aziridinylbenzoquinone RH1
Definitions
A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors.
prefLabel
Aziridinylbenzoquinone RH1
label
Aziridinylbenzoquinone RH1
PDQ_Closed_Trial_Search_ID
580840
code
C29404
prefixIRI
NCIT:C29404
in_subset
Preferred_Name
Aziridinylbenzoquinone RH1
Maps_To
Aziridinylbenzoquinone RH1
NSC Number
697726
NCI_Drug_Dictionary_ID
580840
Legacy Concept Name
RH1
type
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
580840
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0764431
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