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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C29399
http://purl.obolibrary.org/obo/NCIT_C29399
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|---|---|
| Preferred Name | Quinine Sulfate |
| Definitions |
The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
|---|---|
| prefLabel | Quinine Sulfate
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| label | Quinine Sulfate
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| CHEBI_ID | CHEBI:52250
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| code | C29399
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| prefixIRI | NCIT:C29399
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| in_subset | |
| Preferred_Name | Quinine Sulfate
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| FDA_UNII_Code | KF7Z0E0Q2B
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| Contributing_Source | FDA
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| Chemical_Formula | 2C20H24N2O2.2H2O.H2SO4
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| CAS_Registry | 207671-44-1
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| NSC Number |
5362
667852
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| Legacy Concept Name | Quinine_Sulfate
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0034422
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