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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C29367
http://purl.obolibrary.org/obo/NCIT_C29367
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|---|---|
| Preferred Name | Pioglitazone Hydrochloride |
| Definitions |
The hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI05)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI05) |
|---|---|
| prefLabel | Pioglitazone Hydrochloride
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| label | Pioglitazone Hydrochloride
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| PDQ_Closed_Trial_Search_ID | 398145
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| code | C29367
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| prefixIRI | NCIT:C29367
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| in_subset |
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| Display_Name | Pioglitazone Hydrochloride
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| Preferred_Name | Pioglitazone Hydrochloride
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| FDA_UNII_Code | JQT35NPK6C
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C19H20N2O3S.HCl
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| Maps_To | Pioglitazone Hydrochloride
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| CAS_Registry | 112529-15-4
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| NCI_Drug_Dictionary_ID | 398145
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| Legacy Concept Name | Pioglitazone
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| ALT_DEFINITION | A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth) from developing into cancer. It is a type of thiazolidinedione.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 398145
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0872972
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