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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C29322
http://purl.obolibrary.org/obo/NCIT_C29322
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|---|---|
| Preferred Name | Phosphoramide Mustard |
| Definitions |
One of a number of chemically-related alkylating agents with antineoplastic properties. The prototype of this group of agents is cyclophosphamide. Most phosphoramide mustards are administered as prodrugs that undergo reductive activation in hypoxic environments to yield cytotoxic metabolites. These agents alkylate and crosslink DNA, resulting in inhibition of DNA replication. Phosphoramide mustards are also immunosuppressants, mutagens and teratogens. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | One of a number of chemically-related alkylating agents with antineoplastic properties. The prototype of this group of agents is cyclophosphamide. Most phosphoramide mustards are administered as prodrugs that undergo reductive activation in hypoxic environments to yield cytotoxic metabolites. These agents alkylate and crosslink DNA, resulting in inhibition of DNA replication. Phosphoramide mustards are also immunosuppressants, mutagens and teratogens. (NCI04) |
|---|---|
| prefLabel | Phosphoramide Mustard
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| label | Phosphoramide Mustard
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| CHEBI_ID | CHEBI:8163
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| code | C29322
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| prefixIRI | NCIT:C29322
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| in_subset | |
| Preferred_Name | Phosphoramide Mustard
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| Maps_To | Phosphoramide Mustard
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| Legacy Concept Name | Phosphoramide_Mustard
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Organic Chemical
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| UMLS_CUI | C0070913
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