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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C29317
http://purl.obolibrary.org/obo/NCIT_C29317
|
|---|---|
| Preferred Name | Inalimarev |
| Definitions |
A cancer vaccine comprised of a recombinant vaccinia viral vector encoding the carcinoembryonic antigen (CEA), MUC-1 (mucin-1), a transmembrane glycoprotein secreted by glandular tissues, and TRICOM, comprised of the three co-stimulatory molecule transgenes B7-1, ICAM-1 and LFA-3. Upon administration, inalimarev may enhance CEA and MUC-1 presentation to antigen presenting cells (APC) and may activate a cytotoxic T lymphocyte (CTL) response against CEA- and MUC-1-expressing tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cancer vaccine comprised of a recombinant vaccinia viral vector encoding the carcinoembryonic antigen (CEA), MUC-1 (mucin-1), a transmembrane glycoprotein secreted by glandular tissues, and TRICOM, comprised of the three co-stimulatory molecule transgenes B7-1, ICAM-1 and LFA-3. Upon administration, inalimarev may enhance CEA and MUC-1 presentation to antigen presenting cells (APC) and may activate a cytotoxic T lymphocyte (CTL) response against CEA- and MUC-1-expressing tumor cells. |
|---|---|
| prefLabel | Inalimarev
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| label | Inalimarev
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| PDQ_Closed_Trial_Search_ID | 385666
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| code | C29317
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| Has_Target | |
| prefixIRI | NCIT:C29317
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| in_subset |
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| Display_Name | Inalimarev
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| Preferred_Name | Inalimarev
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| Contributing_Source | CTRP
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| Maps_To | Inalimarev
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| CAS_Registry | 685563-13-7
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| NSC Number | 727026
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| NCI_Drug_Dictionary_ID | 385666
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| Legacy Concept Name | rVaccinia-CEA_D609_MUC1_L93_TRICOM
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| type | |
| ALT_DEFINITION | A cancer vaccine made with a form of vaccinia virus that does not cause disease in humans. It is being studied in the treatment of some types of cancer. The virus is changed in the laboratory to make human proteins, including the tumor markers called CEA and MUC-1, that may help immune cells in the body kill tumor cells.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 385666
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| Semantic_Type |
Pharmacologic Substance
Virus
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| UMLS_CUI | C1541349
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