Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C29316
http://purl.obolibrary.org/obo/NCIT_C29316
Preferred Name

Falimarev
Definitions
A cancer vaccine comprised of a recombinant fowlpox viral vector encoding the carcinoembryonic antigen (CEA), MUC-1, a transmembrane glycoprotein secreted by glandular epithelial tissues, and TRICOM, comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3). This agent may enhance CEA and MUC-1 presentation to antigen-presenting cells (APC) and may activate a cytotoxic T-cell response against CEA- and MUC-1-expressing tumor cells.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A cancer vaccine comprised of a recombinant fowlpox viral vector encoding the carcinoembryonic antigen (CEA), MUC-1, a transmembrane glycoprotein secreted by glandular epithelial tissues, and TRICOM, comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3). This agent may enhance CEA and MUC-1 presentation to antigen-presenting cells (APC) and may activate a cytotoxic T-cell response against CEA- and MUC-1-expressing tumor cells.
prefLabel
Falimarev
label
Falimarev
PDQ_Closed_Trial_Search_ID
385667
code
C29316
Has_Target
prefixIRI
NCIT:C29316
in_subset
Display_Name
Falimarev
Preferred_Name
Falimarev
Contributing_Source
CTRP
Maps_To
Falimarev
CAS_Registry
685563-14-8
NSC Number
727027
NCI_Drug_Dictionary_ID
385667
Legacy Concept Name
rFowlpox-CEA_D609_MUC1_L93_TRICOM
type
ALT_DEFINITION
A cancer vaccine made with a form of a chicken virus that does not cause disease in humans. It is being studied in the treatment of some types of cancer. The virus is changed in the laboratory to make human proteins that may help immune cells in the body kill tumor cells.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
385667
Semantic_Type
Pharmacologic Substance
Virus
UMLS_CUI
C1541350
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