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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C29198
http://purl.obolibrary.org/obo/NCIT_C29198
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|---|---|
| Preferred Name | Monoclonal Antibody 1F5 |
| Definitions |
A murine monoclonal antibody directed against CD20, a cross-membrane ion channel phosphoprotein expressed by B cells, with potential antineoplastic activity. MOAB 1F5 binds to CD20, thereby directly inhibiting B-cell proliferation and differentiation. When cross-linked by secondary anti-mouse antibodies or Fc receptor-bearing cells, MOAB 1F5 may induce activation of B-cell protein tyrosine kinases, increases in B-cell intracellular calcium ion concentrations, and B-cell caspase activation, resulting in apoptosis of B cells expressing CD20. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A murine monoclonal antibody directed against CD20, a cross-membrane ion channel phosphoprotein expressed by B cells, with potential antineoplastic activity. MOAB 1F5 binds to CD20, thereby directly inhibiting B-cell proliferation and differentiation. When cross-linked by secondary anti-mouse antibodies or Fc receptor-bearing cells, MOAB 1F5 may induce activation of B-cell protein tyrosine kinases, increases in B-cell intracellular calcium ion concentrations, and B-cell caspase activation, resulting in apoptosis of B cells expressing CD20. (NCI04) |
|---|---|
| prefLabel | Monoclonal Antibody 1F5
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| label | Monoclonal Antibody 1F5
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| code | C29198
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| prefixIRI | NCIT:C29198
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| in_subset | |
| Preferred_Name | Monoclonal Antibody 1F5
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| Maps_To | Monoclonal Antibody 1F5
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| Legacy Concept Name | Monoclonal_Antibody_1F5
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
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| UMLS_CUI | C1513414
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