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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C29195
http://purl.obolibrary.org/obo/NCIT_C29195
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|---|---|
| Preferred Name | Mitindomide |
| Definitions |
A bisdioxopiperazines analog with antineoplastic activity. Mitinomide inhibits topoisomerase II and slowly promotes DNA-interstrand cross-linking, thereby inhibiting DNA repair, RNA and protein synthesis. This agent acts without increasing topoisomerase II-DNA covalent cleavable complex formation, as do most topoisomerase inhibitors. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bisdioxopiperazines analog with antineoplastic activity. Mitinomide inhibits topoisomerase II and slowly promotes DNA-interstrand cross-linking, thereby inhibiting DNA repair, RNA and protein synthesis. This agent acts without increasing topoisomerase II-DNA covalent cleavable complex formation, as do most topoisomerase inhibitors. (NCI04) |
|---|---|
| prefLabel | Mitindomide
|
| label | Mitindomide
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| code | C29195
|
| prefixIRI | NCIT:C29195
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| in_subset | |
| Preferred_Name | Mitindomide
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| FDA_UNII_Code | DK61ZER6T7
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| Contributing_Source | FDA
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| Chemical_Formula | C14H12N2O4
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| Maps_To | Mitindomide
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| CAS_Registry | 10403-51-7
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| NSC Number | 284356
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| Legacy Concept Name | MITINDOMIDE
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0066593
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