Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C29115
http://purl.obolibrary.org/obo/NCIT_C29115
|
|---|---|
| Preferred Name | Imexon |
| Definitions |
A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. (NCI04)
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. (NCI04) |
|---|---|
| label | Imexon
|
| prefLabel | Imexon
|
| Legacy Concept Name | Imexon
|
| in_subset |
See more
See less
|
| Preferred_Name | Imexon
|
| Is_Value_For_GDC_Property | |
| Chemical_Formula | C4H5N3O
|
| Display_Name | Imexon
|
| Maps_To | Imexon
|
| PDQ_Open_Trial_Search_ID | 468469
|
| UMLS_CUI | C0097147
|
| FDA_UNII_Code | 8F63U28T2V
|
| prefixIRI | NCIT:C29115
|
| NCI_Drug_Dictionary_ID | 468469
|
| Contributing_Source |
CTRP
FDA
|
| subClassOf | |
| code | C29115
|
| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of some types of cancer, including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma. It belongs to the family of drugs called cyanoaziridine derivatives.
|
| NSC Number | 714597
|
| PDQ_Closed_Trial_Search_ID | 468469
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| CAS_Registry | 59643-91-3
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |