Preferred Name

Divalproex Sodium
Synonyms
Definitions

A stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.

ID

http://purl.obolibrary.org/obo/NCIT_C28996

CAS_Registry

76584-70-8

CHEBI_ID

CHEBI:4667

Chemical_Formula

2C8H15O2."H".Na

code

C28996

Contributing_Source

FDA

definition

A stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.

FDA_UNII_Code

644VL95AO6

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424

label

Divalproex Sodium

Legacy Concept Name

Divalproex

NCI_Drug_Dictionary_ID

778070

PDQ_Closed_Trial_Search_ID

778070

PDQ_Open_Trial_Search_ID

778070

Preferred_Name

Divalproex Sodium

prefixIRI

NCIT:C28996

prefLabel

Divalproex Sodium

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0886883

subClassOf

http://purl.obolibrary.org/obo/NCIT_C264

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