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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C28990
http://purl.obolibrary.org/obo/NCIT_C28990
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|---|---|
| Preferred Name | Digoxin |
| Definitions |
A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04) |
|---|---|
| prefLabel | Digoxin
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| label | Digoxin
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| CHEBI_ID | CHEBI:4551
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| PDQ_Closed_Trial_Search_ID | 485249
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| code | C28990
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| prefixIRI | NCIT:C28990
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| in_subset |
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| Display_Name | Digoxin
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| Preferred_Name | Digoxin
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| FDA_UNII_Code | 73K4184T59
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C41H64O14
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| Maps_To | Digoxin
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| CAS_Registry | 20830-75-5
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| NSC Number | 95100
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| NCI_Drug_Dictionary_ID | 485249
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| Legacy Concept Name | Digoxin
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| type | |
| ALT_DEFINITION | A drug used to treat irregular heartbeat and some types of heart failure. It is also being studied in the treatment of some types of cancer. Digoxin helps the heart work normally by controlling the amount of calcium that goes into the heart muscle. It also may kill cancer cells and make them more sensitive to anticancer drugs. It is a type of cardiac glycoside.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 485249
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| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0012265
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