loading...| Preferred Name |
Cyproheptadine Hydrochloride |
|
| Synonyms |
|
|
| Definitions |
The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C28949 |
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| Accepted_Therapeutic_Use_For |
Hypersensitivity reactions |
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| CAS_Registry |
41354-29-4 |
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| CHEBI_ID |
CHEBI:650917 CHEBI:59695 |
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| Chemical_Formula |
2C21H21N.2HCl.3H2O |
|
| code |
C28949 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain. (NCI04) |
|
| Display_Name |
Cyproheptadine Hydrochloride |
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| FDA_UNII_Code |
NJ82J0F8QC |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Cyproheptadine Hydrochloride |
|
| Legacy Concept Name |
Cyproheptadine_Hydrochloride |
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| NCI_Drug_Dictionary_ID |
315774 |
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| NSC Number |
169911 |
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| PDQ_Closed_Trial_Search_ID |
315774 |
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| PDQ_Open_Trial_Search_ID |
315774 |
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| Preferred_Name |
Cyproheptadine Hydrochloride |
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| prefixIRI |
NCIT:C28949 |
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| prefLabel |
Cyproheptadine Hydrochloride |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0354872 |
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| subClassOf |